Targeting Neglected Tropical Diseases and Malaria: The Therapeutic Promise of Mannich Bases
Authors:
- Dalila Junqueira AlvarengaDADalila Junqueira Alvarenga
- Paulo José Silva de ToledoPTPaulo José Silva de Toledo
- Jorys César Hegedus FilhoJFJorys César Hegedus Filho
- João Vitor de Souza Nascimento CândidoJCJoão Vitor de Souza Nascimento Cândido
- Lucas Lopardi FrancoLFLucas Lopardi Franco
- Jamie Anthony HawkesJHJamie Anthony Hawkes
- Diogo Teixeira CarvalhoDiogo Teixeira Carvalho
- 17 April 2025
- journal article
- Published by Wiley in Chemistry & Biodiversity
- p. e202403111
Abstract
Neglected tropical diseases (NTDs) and malaria remain significant public health challenges, particularly in resource‐limited regions. The search for novel therapeutic agents to combat these diseases is imperative due to emerging drug resistance and limited treatment options. Mannich bases, a class of organic compounds synthesised via the Mannich reaction, exhibit diverse pharmacological properties, including antimicrobial, antimalarial, antiviral, antimycobacterial, antiparasitic (leishmanicidal, trypanocidal, anthelmintic) and even anti‐diabetic. Their structural versatility allows for modifications to enhance bioavailability, potency and selectivity against specific pathogens. Moreover, Mannich bases can target multiple biological pathways involved in the pathogenesis of NTDs and malaria, thereby offering a multifaceted approach to treatment. This review explores the pharmacological potential of Mannich bases in addressing NTDs and malaria.Keywords
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