Structural basis for semaphorin signalling through the plexin receptor
- 29 September 2010
- journal article
- Published by Springer Nature in Nature
- Vol. 467 (7319) , 1123-1127
Abstract
Semaphorin proteins mediate signal transduction by interacting with plexin receptors; they have key roles in neuronal development and many other biological processes. Here, crystal structures are presented of the semaphorin 6A receptor-binding fragment and the plexin A2 ligand-binding fragment in their pre-signalling and signalling states. On the basis of these structures, a signalling mechanism is proposed.Keywords
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