Facile Method To Sequence Cyclic Peptides/Peptoids via One-Pot Ring-Opening/Cleavage Reaction
Authors:
- 13 October 2014
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 16 (21) , 5710-5713
Abstract
A facile method for sequence determination of cyclic peptides/peptoids is described. Macrocyclic peptides/peptoids of 3–10 residues were efficiently synthesized through thioether formation. One-pot reaction of thioether-embedded cyclic peptides/peptoids involving cyanogen bromide-mediated ring-opening and cleavage provides linearized molecules, which can be efficiently sequenced by tandem mass spectrometry.Keywords
Funding Information
- Division of Chemistry (CHE-1212720)
- National Research Foundation of Korea (2012R1A2007768)
- Basic Science Research Institute, Pohang University of Science and Technology
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