An association between resistant hypertension and the null GSTM1 genotype
Open Access
- 12 March 2009
- journal article
- research article
- Published by Springer Nature in Journal of Human Hypertension
- Vol. 23 (8) , 556-558
Abstract
Reduction in expression levels of glutathione S -transferase (GST) μ type 1 (GSTM1) in stroke-prone spontaneously hypertensive rats has recently been reported. GSTM1 genotype was evaluated in 49 patients with resistant hypertension and compared with selected patients with controlled hypertension ( n =232) and healthy participants ( n =110). Null GSTM1 genotype occurred more frequent in patients with resistant hypertension than those with controlled hypertension (57.1 vs 39.7%; P =0.03; RR 1.96; 95% CI 1.04–3.69) suggesting that null GSTM1 genotype may predispose to resistant hypertension.Keywords
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