Validation of Patient‐Reported Outcomes Information System Sleep Disturbance and Sleep‐Related Impairment in adults with atopic dermatitis*

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Abstract
Background Sleep disturbances (SD) are common in adults with atopic dermatitis (AD). Patient‐Reported Outcomes Measurement Information System (PROMIS™) SD and Sleep‐Related Impairment (SRI) are validated questionnaires to assess sleep in adults. Little is known about their measurement properties in adults with AD. Objective To assess the measurement properties of PROMIS SD and SRI 8‐item short‐forms in AD. Methods We performed a prospective dermatology practice‐based study using questionnaires and evaluation by a dermatologist (n=420). Results PROMIS SD/SRI showed moderate correlations to each other (r=0.57), and weak correlations with Patient‐Oriented Eczema Measure (rho=0.43/0.39), average (rho=0.31/0.30) and worst numerical rating scale for itch (rho=0.32/0.30), Eczema Area and Severity Index (rho=0.41/0.31) and Scoring AD (SCORAD) (rho=0.44/0.30) (Spearman correlations, P<0.0001). PROMIS SD and SRI increased significantly and stepwise with more frequent sleep disturbance, severe itch and self‐reported global AD severity (analysis of covariance, P<0.0001). PROMIS SD and SRI showed good internal consistency (Cronbach’s alpha=0.84, 0.91). Changes from baseline in PROMIS SD and SRI were weakly to moderately correlated with each other and changes of multiple patient‐reported and clinical‐reported AD outcomes. There were no floor or ceiling effects for PROMIS SD or SRI. The median completion time for PROMIS SD and SRI was 2 minutes. Conclusions PROMIS SD and SRI showed good construct validity, internal consistency, responsiveness and feasibility to assess sleep in adult AD patients.
Funding Information
  • Dermatology Foundation
  • Agency for Healthcare Research and Quality (K12HS023011)
  • Galderma

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