Adaptation to mitochondrial stress requires CHOP-directed tuning of ISR
Authors:
- Sophie KasparSKSophie Kaspar
- Karolina SzczepanowskaKarolina Szczepanowska
- Alexandra KukatAKAlexandra Kukat
- Katharina SenftKSKatharina Senft
- Christina LucasChristina Lucas
- Susanne BrodesserSusanne Brodesser
- Maria HatzoglouMaria Hatzoglou
- Ola LarssonOla Larsson
- Ivan TopisirovicIvan Topisirovic
- Aleksandra TrifunovicAleksandra Trifunovic
Open Access
- 28 May 2021
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Advances
- Vol. 7 (22) , eabf0971
Abstract
Upon mitochondrial dysfunction, CHOP acts as a rheostat that attenuates prolonged stress and delays the onset of cardiomyopathy.Keywords
Funding Information
- National Institutes of Health (NIH R01 DK060596)
- Deutsche Forschungsgemeinschaft (SFB 1218 – Projektnummer 269925409 and TR 1018/8-1)
- Deutsche Forschungsgemeinschaft (SFB 1218)
- Deutsche Forschungsgemeinschaft (269925409)
- Deutsche Forschungsgemeinschaft (TR 1018/8-1)
- Cancerfonden (19 0314)
- Vetenskapsrådet (2016-02891)
- Marianne and Marcus Wallenberg Foundation (2013.0181)
- Canadian Institutes for Health Research (MOP-363027)
- Joint Canada-Israel Health Research Program (108589-001)
This publication has 76 references indexed in Scilit:
- ER-stress-induced transcriptional regulation increases protein synthesis leading to cell deathNature Cell Biology, 2013
- Transcriptional Repression of ATF4 Gene by CCAAT/Enhancer-binding Protein β (C/EBPβ) Differentially Regulates Integrated Stress ResponseJournal of Biological Chemistry, 2012
- Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitisHepatology, 2011
- Bioenergetics, mitochondria, and cardiac myocyte differentiationProgress in Pediatric Cardiology, 2011
- Molecular Symbiosis of CHOP and C/EBPβ Isoform LIP Contributes to Endoplasmic Reticulum Stress-Induced ApoptosisMolecular and Cellular Biology, 2010
- A scaling normalization method for differential expression analysis of RNA-seq dataGenome Biology, 2010
- ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networksBioinformatics, 2009
- A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvationBiochemical Journal, 2007
- Cytoscape: A Software Environment for Integrated Models of Biomolecular Interaction NetworksGenome Research, 2003
- An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative StressMolecular Cell, 2003