ESR1gene promoter region methylation in free circulating DNA and its correlation with estrogen receptor protein expression in tumor tissue in breast cancer patients
Authors:
- Joaquina Martínez-GalánJMJoaquina Martínez-Galán
- Blanca Torres-TorresBTBlanca Torres-Torres
- María Isabel NúñezMNMaría Isabel Núñez
- Jesús López-PeñalverJLJesús López-Peñalver
- Rosario Del MoralRMRosario Del Moral
- José Mariano Ruiz De AlmodóvarJAJosé Mariano Ruiz De Almodóvar
- Salomón MenjónSMSalomón Menjón
- Ángel ConchaÁCÁngel Concha
- Clara ChamorroCCClara Chamorro
- Sandra RíosSRSandra Ríos
- Juan Ramón DelgadoJDJuan Ramón Delgado
Open Access
- 4 February 2014
- journal article
- research article
- Published by Springer Nature in BMC Cancer
- Vol. 14 (1) , 59
Abstract
Tumor expression of estrogen receptor (ER) is an important marker of prognosis, and is predictive of response to endocrine therapy in breast cancer. Several studies have observed that epigenetic events, such methylation of cytosines and deacetylation of histones, are involved in the complex mechanisms that regulate promoter transcription. However, the exact interplay of these factors in transcription activity is not well understood. In this study, we explored the relationship between ER expression status in tumor tissue samples and the methylation of the 5′ CpG promoter region of the estrogen receptor gene (ESR1) isolated from free circulating DNA (fcDNA) in plasma samples from breast cancer patients.Keywords
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