Osteogenic Enhancement of Zirconia-Toughened Alumina with Silicon Nitride and Bioglass®
Authors:
- Giuseppe PezzottiGPGiuseppe Pezzotti
- Elia MarinElia Marin
- Matteo ZanoccoMZMatteo Zanocco
- Francesco BoschettoFrancesco Boschetto
- Wenliang ZhuWZWenliang Zhu
- Bryan J. McEntireBMBryan J. McEntire
- B. Sonny BalBBB. Sonny Bal
- Tetsuya AdachiTATetsuya Adachi
- Toshiro YamamotoTYToshiro Yamamoto
- Narisato KanamuraNKNarisato Kanamura
- Osam MazdaOMOsam Mazda
Open Access
Abstract
Alumina (Al2O3) ceramic implants do not stimulate osteoblasts in vivo. Surface alterations targeted at changing the chemistry or topography have been proposed to enhance the bioactivity of alumina. This surface modification is intended to improve oxide bioceramic’s ability to integrate with the biological environment and, in particular, to rapidly osteointegrate. In this study, the surface of zirconia-toughened alumina (ZTA) was functionalized using two methods: (i) Surface laser-patterning and successive filling of patterned wells with powder mixtures of bioglass and Si3N4; and, (ii) Si3N4 coating by pulse-laser sintering. Functionalized ZTA surfaces were characterized with vibrational spectroscopy, biological testing, and laser microscopy. Both enhancements resulted in osteoblast activation, a property that is relevant to osteosynthesis.Keywords
This publication has 48 references indexed in Scilit:
- Human osteoblasts grow transitional Si/N apatite in quickly osteointegrated Si3N4 cervical insertActa Biomaterialia, 2017
- Silicon nitride surface chemistry: A potent regulator of mesenchymal progenitor cell activity in bone formationApplied Materials Today, 2017
- Bioinert Ceramics: State-of-the-ArtKey Engineering Materials, 2017
- Bioactive silicon nitride: A new therapeutic material for osteoarthropathyScientific Reports, 2017
- Activation of apoptosis signalling pathways by reactive oxygen speciesBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
- Silicon Nitride: A Synthetic Mineral for Vertebrate BiologyScientific Reports, 2016
- Anti-infective and osteointegration properties of silicon nitride, poly(ether ether ketone), and titanium implantsActa Biomaterialia, 2012
- Osteoblasts in bone tissue engineeringProceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 2010
- Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralizationProceedings of the National Academy of Sciences, 2002
- Bioceramics: From Concept to ClinicJournal of the American Ceramic Society, 1991