Vitamin D3levels and bone mineral density in patients with psoriasis and/or psoriatic arthritis

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Abstract
Limited data are available on the vitamin D3status and bone mineral density (BMD) of patients with psoriasis or with psoriatic arthritis. Our study intended to explore possible correlations between vitamin D status andBMD, as well as among these parameters and the features of the underlying disorder. Seventy‐two patients with psoriasis/or psoriatic arthritis (female : male ratio, 40:32; mean age, 58.5 ± 11.6 years; mean duration of follow up, 142.7 ± 147.7 months) participated in the study. We evaluated the characteristic clinical features of the underlying disease, performed bone densitometry of the lumbar spine and the hip region, measured the serum vitamin 25(OH)D3levels of the patients, and undertook the statistical analysis of the relationships between the clinical and the laboratory parameters. The proportion of patients with a lowBMDvalue did not exceed that seen in the general population. We found an inverse correlation between the serum level of vitamin 25(OH)D3and body mass index, as well as between the former and the severity of skin involvement. Furthermore, the activity of psoriatic arthritis was significantly higher in patients with inadequate vitamin D3status. In patients with psoriatic arthritis,BMDsignificantly exceeded the values measured in patients suffering from psoriatic skin lesions only. Our findings suggest the importance of evaluating the vitamin D3status and screening for comorbid conditions in patients with psoriasis or psoriatic arthritis. This appears justified, in particular, due to the possible role of hypovitaminosis D3in provoking the development of skin lesions and joint symptoms.

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