Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients
Authors:
Open Access
- 31 August 2021
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 326 (10) , 940-948
Abstract
Oxygen is often liberally administered in the intensive care unit (ICU) to treat or prevent hypoxemia. For many years, oxygen was considered to have consistently favorable effects. However, an observational study using data from 1999 to 2006 showed a U-shaped relationship between Pao2 and mortality,1 opening a debate about optimal oxygenation targets in critically ill patients.Keywords
This publication has 31 references indexed in Scilit:
- Reporting and analysis of trials using stratified randomisation in leading medical journals: review and reanalysisBMJ, 2012
- Hemodynamic, metabolic, and organ function effects of pure oxygen ventilation during established fecal peritonitis-induced septic shockCritical Care Medicine, 2009
- Association between administered oxygen, arterial partial oxygen pressure and mortality in mechanically ventilated intensive care unit patientsCritical Care, 2008
- Effects of ventilation with 100% oxygen during early hyperdynamic porcine fecal peritonitis*Critical Care Medicine, 2008
- Variation in the PaO2/FiO2 ratio with FiO2: mathematical and experimental description, and clinical relevanceCritical Care, 2007
- Comparison of the Sp o 2 /F io 2 Ratio and the Pa o 2 /F io 2 Ratio in Patients With Acute Lung Injury or ARDSChest, 2007
- Stratified Randomization for Clinical TrialsJournal of Clinical Epidemiology, 1999
- Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in SepsisChest, 1992
- The oxygen status of arterial human bloodScandinavian Journal of Clinical and Laboratory Investigation, 1990
- Discrete sequential boundaries for clinical trialsBiometrika, 1983