A Review of Refractive Errors Post Anti-Vascular Endothelial Growth Factor Injection and Laser Photocoagulation Treatment for Retinopathy of Prematurity

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Abstract
Background/Objectives: The aim of this study was to examine the incidence and severity of refractive errors that occur following the treatment of retinopathy of prematurity (ROP) with anti-vascular growth factor (anti-VEGF) agents and laser photocoagulation. Methods: A review of the literature using three databases (PubMed, Embase, Medline) was performed using appropriate search terms, and the results of the relevant studies were compiled and extracted for descriptive analysis. Results: Sixty articles were identified. The cohorts in the studies were treated with either anti-VEGF monotherapy, laser photocoagulation, or a combination, with a high prevalence of myopia, ranging from 0 to 47.7%. Refractive errors of myopia, hypermetropia, astigmatism, and anisometropia were considered in infants who received ocular interventions for ROP. Conclusions: In comparison to laser photocoagulation, anti-VEGF monotherapy appears to yield lower levels of myopia and anisometropia; however, the incidence of hypermetropia and astigmatism is variable among cohort groups treated with different anti-VEGF agents.

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