New tricks of an old autophagy regulator: AMPK-dependent regulation of autophagy through CCNY (cyclin Y)-CDK16
- 13 May 2020
- journal article
- editorial
- Published by Taylor & Francis in Autophagy
- Vol. 16 (6) , 973-974
Abstract
AMPK is one of the main regulators of energy homeostasis in the cell, achieving this role in part by upregulating autophagy in times of nutrient deprivation. Previous reports have described several AMPK substrates involved in autophagy regulation; however, there are still undiscovered AMPK downstream effectors that could play an important role in autophagy. In a new article, Dohmen et al. discovered that the CCNY-CDK16 complex is a novel AMPK substrate involved in autophagy activation.Keywords
Funding Information
- National Institute of General Medical Sciences (GM131919)
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