Quantitative Aspects of Contrast Enhancement in Cranial Computed Tomography
Authors:
- David NormanDNDavid Norman
- Edwin A. StevensESEdwin A. Stevens
- S. Douglas WingSWS. Douglas Wing
- Victor LevinVLVictor Levin
- Thomas H. NewtonTNThomas H. Newton
- 1 December 1978
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 129 (3) , 683-688
Abstract
The temporal relationship of blood iodine levels to tumor enhancement in cranial computed tomography was studied in a series of patients. Both the bolus and biphasic techniques were evaluated. Peak tumor intensity may not develop immediately, but may be more pronounced on a 20-minute scan. The low-density centers seen in malignant gliomas show delayed enhancement. These low-density centers represent a second compartment which equilibrates with the intravascular and interstitial contrast material at a much slower rate. Patients with malignant gliomas can be scanned up to one hour following contrast injection without significant loss of information.Keywords
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