Inactivation of Biologically Active DNA by Isopropanol and Formate Radicals
Authors:
- Frans J. NabbenFNFrans J. Nabben
- H.A. van der StroomHSH.A. van der Stroom
- H. LomanHLH. Loman
- 1 January 1983
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 43 (5) , 495-504
Abstract
If OH and H radicals, produced by absorption of ionizing radiation in aqueous solutions, are scavenged with isopropanol or sodium formate, secondary radicals are formed which can inactivate [phage] .vphi.X174 DNA. From experiments at various DNA concentrations and dose rates, one could determine the rate constant and the inactivation efficiency of the reaction of these organic radicals with single stranded DNA.Keywords
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