Effect of Dietary Vitamin E on the Activities of the Glutathione Peroxidase System in Rat Tissues

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Abstract
The effect of dietary α-tocopherol on activities of enzymes important in protection against lipid peroxidation was studied in tissues of rats. The activities of glutathione (GSH) peroxidase, GSH reductase and glucose-6-phosphate (G-6-P) dehydrogenase were significantly increased in perirenal adipose (PRA), paraepididymal adipose (PEA) and muscle, but not in liver, lung and kidney of animals fed a 15.7% tocopherol-stripped corn oil diet. The activities of GSH reductase and G-6-P dehydrogenase, but not GSH peroxidase, were also significantly increased in testes of rats fed the corn oil diets. Accumulation of fluorescent products (FP) in PEA and PRA of these animals was also increased. There are close linear relationships among these measurements. The increases in activities of the GSH peroxidase system in PEA, PRA, muscle and testes of rats fed the corn oil diets appear to be in response to the lipid peroxidation which occurred in these tissues. Except for muscle and testes, similar increases in the activities of GSH peroxidase and GSH reductase were found in tissues of rats fed a diet that contained 15.7% cod-liver oil.

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