Mutation induction in chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2‐chloroacetaldehyde
Authors:
- 15 October 1975
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 16 (4) , 639-644
Abstract
Chloroethylene oxide and 2‐chloroacetaldehyde, two possibly carcinogenic metabolites of vinyl chloride in mammals, caused a dose‐dependent induction of 8‐azaguanine‐and ouabain‐resistant mutants in Chinese hamster V79 cells in vitro. Up to one‐hundredfold higher concentrations of 2‐chloroethanol or monochloroacetic acid, a urinary vinyl chloride metabolite in rats and man, were inactive.Keywords
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