5‐Fluorouracil encapsulated magnetic nanohydrogels for drug‐delivery applications

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Abstract
For the first time, green‐tea (GT)‐based magnetic nanohydrogels were developed for drug‐delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5‐fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X‐ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43921.
Funding Information
  • National Research Foundation of Korea (NRF-2015R1A3A2066301)
  • PAI (781302011)
  • Comisión Nacional de Investigación Científica y Tecnológica de Chile
  • Centro de Investigación de Polímeros Avanzados
  • Comisión Nacional de Investigación Científica y Tecnológica (Regional)
  • Gobierno Regional del Biobío (R08C1002)

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