Mortality and morbidity of asthma and chronic obstructive pulmonary disease associated with ambient environment in metropolitans in Taiwan

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Abstract
Background: This study investigated risks of mortality from and morbidity (emergency room visits (ERVs) and outpatient visits) of asthma and chronic obstructive pulmonary disease (COPD) associated with extreme temperatures, fine particulate matter (PM2.5), and ozone (O3) by sex, and age, from 2005 to 2016 in 6 metropolitan cities in Taiwan.Methods: The distributed lag non-linear model was employed to assess age (0–18, 19–39, 40–64, and 65 years and above), sex-cause-specific deaths, ERVs, and outpatient visits associated with extreme high (99thpercentile) and low (5thpercentile) temperatures and PM2.5and O3concentrations at 90thpercentile. Random-effects meta-analysis was adopted to investigate cause-specific pooled relative risk (RR) and 95% confidence intervals (CI) for the whole studied areas.Results: Only the mortality risk of COPD in the elderly men was significantly associated with the extreme low temperatures. Exposure to the 90thpercentile PM2.5was associated with outpatient visits for asthma in 0–18 years old boys [RR = 1.15 (95% CI: 1.09–1.22)]. Meanwhile, significant elevation of ERVs of asthma for females aged 40–64 years was associated with exposure to ozone, with the highest RR of 1.21 (95% CI: 1.05–1.39).Conclusions: This study identified vulnerable subpopulations who were at risk to extreme events associated with ambient environments deserving further evaluation for adaptation.
Funding Information
  • Ministry of Science and Technology, Taiwan (MOST 108-2625-M-033-002)
  • Ministry of Science and Technology, Taiwan (MOST 109-2625-M-033-002)
  • Ministry of Science and Technology, Taiwan (MOST 106-2221-E-033-006-MY2)
  • National Health Research Institutes (NHRI-107A1-EMCO-3617191)
  • National Health Research Institutes (NHRI-106A1-PDCO-3617191)
  • Taiwan Ministry of Health and Welfare Clinical Trial Center (MOHW109-TDU-B-212-114004)
  • Taiwan Environmental Protection Administration
  • Clinical Trial Consortium for Stroke (MOST 109-2321-B-039-002)
  • Tseng-Lien Lin Foundation
  • National Health Research Institutes (MOHW105-TDU-M-212-113003)

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