Effect of On-Demand vs Routine Nebulization of Acetylcysteine With Salbutamol on Ventilator-Free Days in Intensive Care Unit Patients Receiving Invasive Ventilation
Open Access
- 13 March 2018
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 319 (10) , 993-1001
Abstract
Mucus plugging can increase morbidity and mortality in intensive care unit (ICU) patients receiving invasive ventilation.1 Mucociliary clearance could be impaired because of the presence of the endotracheal tube. Ventilation with relatively dry gases may lead to dehydration of the mucosa, increasing bronchial mucus production. Furthermore, an inadequate cough reflex resulting from depressed levels of consciousness, sedation, and paralysis puts ICU patients receiving invasive ventilation at increased risk of airway obstruction and atelectasis, eventually leading to airway colonization and respiratory infections.2,3Keywords
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