Promiscuity Rules? The Dispensability of Cyclin E and Cdk2
Authors:
- 16 March 2004
- journal article
- review article
- Published by American Association for the Advancement of Science (AAAS) in Science's STKE
- Vol. 2004 (224) , pe11
Abstract
The canonical view of the mammalian cell cycle arose from studies of cultured cells rather than mutant organisms. It depicts the many complexes of cyclin and Cdk (cyclin/Cdk) as fulfilling unique and essential steps that dictate the sequential order of cell cycle events. Recent analyses of knockout mice challenge this view. Cdk2 and cyclin E, long thought to be essential, are largely dispensable. Here, we discuss the phenotypes of these and other cyclin/Cdk mutants in genetically tractable metazoa (mouse, fly, and nematode) and explore possible reasons behind similarities and differences among experimental systems and cell types.Keywords
This publication has 26 references indexed in Scilit:
- Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in miceNature Genetics, 2003
- Cyclin E Ablation in the MouseCell, 2003
- Unmasking the S-Phase-Promoting Potential of Cyclin B1Science, 2003
- To cycle or not to cycle: a critical decision in cancerNature Reviews Cancer, 2001
- roughex down-regulates G2 cyclins in G1.Genes & Development, 1997
- Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F.Genes & Development, 1995
- Distinct modes of cyclin E/cdc2c kinase regulation and S-phase control in mitotic and endoreduplication cycles of Drosophila embryogenesis.Genes & Development, 1995
- Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferationCell, 1994
- Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle ControlScience, 1993
- Cyclin a is required for the onset of DNA replication in mammalian fibroblastsCell, 1991