Reference Ranges for NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) and Risk Factors for Higher NT-proBNP Concentrations in a Large General Population Cohort
Authors:
- Paul WelshPWPaul Welsh
- Leanne MooneyLMLeanne Mooney
- Dorien M. KimenaiDKDorien M. Kimenai
- Caroline HaywardCHCaroline Hayward
- Archie CampbellACArchie Campbell
- David PorteousDPDavid Porteous
- Nicholas L. MillsNMNicholas L. Mills
- Ninian N. LangNLNinian N. Lang
- Mark C. PetrieMPMark C. Petrie
- James L. JanuzziJJJames L. Januzzi
- John J.V. McMurrayJMJohn J.V. McMurray
Top Cited Papers
Open Access
- 13 September 2022
- journal article
- research article
- Published by Wolters Kluwer Health in Circulation: Heart Failure
- Vol. 15 (10) , e009427
Abstract
Background: Demographic differences in expected NT-proBNP (N-terminal pro-B-type natriuretic peptide) concentration are not well established. We aimed to establish reference ranges for NT-proBNP and explore the determinants of moderately elevated NT-proBNP under the universal definition of heart failure criteria. Methods: This is a cross-sectional study. NT-proBNP was measured in serum from 18 356 individuals without previous cardiovascular disease in the Generation Scotland Scottish Family Health Study. Age- and sex-stratified medians and 97.5th centiles were generated. Sex stratified risk factors for moderately elevated NT-proBNP (≥125 pg/mL) were investigated. Results: In males, median (97.5th centile) NT-proBNP concentration at age P sex interaction P sex interaction =0.007). Conclusions: An NT-proBNP ≥125 pg/mL is common in females without classical cardiovascular risk factors as well as older people. If NT-proBNP becomes widely used for screening in the general population, interpretation of NT-proBNP levels will require that age and sex-specific thresholds are used to identify patients with potential pathophysiology.Keywords
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