Relation of Serum Leptin to Blood Pressure of Japanese in Japan and Japanese-Americans in Hawaii
Authors:
- Yasuyuki NakamuraYNYasuyuki Nakamura
- Hirotsugu UeshimaHUHirotsugu Ueshima
- Nagako OkudaNONagako Okuda
- Yoshitaka MurakamiYMYoshitaka Murakami
- Katsuyuki MiuraKMKatsuyuki Miura
- Yoshikuni KitaYKYoshikuni Kita
- Tomonori OkamuraTomonori Okamura
- Tanvir C. TurinTanvir C. Turin
- Beatriz RodriguezBRBeatriz Rodriguez
- J. David CurbJCJ. David Curb
- Jeremiah StamlerJSJeremiah Stamler
- 1 December 2009
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 54 (6) , 1416-1422
Abstract
Data from animal studies clearly indicate an association between leptin and hypertension; results of human studies are less concordant. We investigated the role of leptin in obesity-related higher blood pressure (BP) in Japanese Americans living in Hawaii and Japanese in Japan. Serum leptin and BP were examined by standardized methods in men and women ages 40 to 59 years from 2 population samples, one Japanese American in Hawaii (88 men and 94 women) and the other Japanese in central Japan (123 men and 111 women). Multiple linear regression models were used to assess role of leptin in obesity-related higher BP. Across quartiles of leptin, there were significantly higher mean body mass index levels, systolic BP, and diastolic BP for both sexes and sites ( P P <0.01 to <0.05). These findings are consistent with the inference that leptin may be an independent mediator for obesity-related elevations in BP.Keywords
This publication has 26 references indexed in Scilit:
- Coronary Artery Calcification in Japanese Men in Japan and HawaiiAmerican Journal of Epidemiology, 2007
- Hemodynamic monitoring in obese patients: The impact of body mass index on cardiac output and stroke volume*Critical Care Medicine, 2006
- Role of leptin in the cardiovascular and endocrine complications of metabolic syndromeDiabetes, Obesity and Metabolism, 2006
- Relation of long chain n-3 polyunsaturated fatty acid intake to serum high density lipoprotein cholesterol among Japanese men in Japan and Japanese–American men in Hawaii: the INTERLIPID studyAtherosclerosis, 2005
- Differences in cardiovascular disease risk factors between Japanese in Japan and Japanese-Americans in Hawaii: the INTERLIPID studyJournal of Human Hypertension, 2003
- INTERMAP: the dietary data—process and quality controlJournal of Human Hypertension, 2003
- Pathophysiological role of leptin in obesity-related hypertensionJournal of Clinical Investigation, 2000
- Positional cloning of the mouse obese gene and its human homologueNature, 1994
- A Sample Size Formula for Multiple Regression StudiesPublic Opinion Quarterly, 1986
- Epidemiologic studies of coronary heart disease and stroke in Japanese men living in Japan, Hawaii and California: Demographic, physical, dietary and biochemical characteristicsJournal of Chronic Diseases, 1974