Auxiliary Liver Homotransplantation

Authors:
  • MSMaurice Slapak
    Maurice Slapak
  • JBJean Guy Beaudoin
    Jean Guy Beaudoin
  • HLHung Mo Lee
    Hung Mo Lee
  • DHDavid M. Hume
    David M. Hume
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Abstract
An acceptable method for experimental or clinical auxiliary liver transplantation should fulfill the following criteria: The donor liver must be vascularized sufficiently to prevent shrinkage, dysfunction, and histopathological changes distinct from any subsequent immunological damage. Donor liver function must be easily and accurately assessable so that reliable comparisons can be made of different immunosuppressive methods. Function should be assessable by means of blood biochemical measurements without the need of an external biliary fistula. The method must be sufficiently sparing of technical difficulties and make use of skilled personnel so that a low number of deaths due to technical problems ensue. Thus, experimentally, a sufficiently large number of animals can be maintained for observation and statistical analysis of data. A study of the literature of heterotopic liver transplantation reveals confusing inconsistencies by different authors in the criteria used to assess donor liver function in the presence of a