Novel method for dealkylation of esters, ethers, and acetals by chlorotrimethylsilane–sodium iodide

Authors:
  • TMTsuyoshi Morita
    Tsuyoshi Morita
  • YOYoshiki Okamoto
    Yoshiki Okamoto
  • HSHiroshi Sakurai
    Hiroshi Sakurai
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Abstract
Reactions of the carboxylic esters (1) and the ethers (5) with chlorotrimethylsilane (2) in the presence of sodium iodide give the silyl derivatives (3) and (6) quantitatively which are easily converted into the corresponding carboxylic acids (4) and phenols (7) under mild conditions.