Tumor Angiogenesis Change Estimated by Using Diffuse Optical Spectroscopic Tomography: Demonstrated Correlation in Women Undergoing Neoadjuvant Chemotherapy for Invasive Breast Cancer?

Authors:
  • MSMary C. Schwab
    Mary C. Schwab
  • HFHeather M. Froehlich
    Heather M. Froehlich
  • SJShudong Jiang
    Shudong Jiang
  • ZLZhongze Li
    Zhongze Li
  • TTTor D. Tosteson
    Tor D. Tosteson
  • SPSteven P. Poplack
    Steven P. Poplack
  • PKPeter A. Kaufman
    Peter A. Kaufman
  • KPKeith D. Paulsen
    Keith D. Paulsen
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Abstract
Our study results show a correlation between changes in total tissue hemoglobin at diffuse optical spectroscopic tomography and tumor angiogenesis and demonstrate how this noninvasive modality might allow individualization and optimization of neoadjuvant chemotherapy regimens. PurposeTo investigate if changes in tumor angiogenesis associated with complete pathologic response (pCR) or partial pathologic response (pPR) to treatment can be demonstrated by using diffuse optical spectroscopic (DOS) tomography.Materials and MethodsAll participants in this prospective, HIPAA-compliant, institutional review board–approved study provided written informed consent. Eleven women with invasive breast carcinoma were imaged with DOS tomography prior to, during, and at completion of neoadjuvant chemotherapeutic regimens. By using region of interest (ROI) analysis, the DOS measure of total tissue hemoglobin (HbT) was temporally correlated with quantitative measures of existing (CD31-expressing) and tumor-induced (CD105-expressing) vessels, in pretreatment and posttreatment tissue specimens, to assess change.ResultsQuantified angiogenesis alone in pretreatment core biopsy specimens did not predict treatment response, but mean vessel density (MVD) and mean vessel area (MVA) of CD105-expressing ve...

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