Relationship of cytogenetic subtypes of salivary gland pleomorphic adenomas with patient age and histologic type
Authors:
Abstract
Sixty-nine salivary gland pleomorphic adenomas were fully karyotyped by G-banding including 40 tumors previously reported. The cytogenetic results allowed to distinguish between three major chromosomal subgroups characterized by either an apparently normal karyotype or by rearrangements of chromosome 8q12 or by rearrangements of chromosome 12q14–15. Significant correlations of these karyotypic groups with the age of the patients and histologic subgroups of the pleomorphic adenomas were found. Furthermore, our analysis revealed that the three main cytogenetic subgroups showed an uneven geographical distribution. Based on these results we have concluded that the cytogenetic groups represent different etiologic entities.Keywords
This publication has 8 references indexed in Scilit:
- Expression of the int-1 gene in transgenic mice is associated with mammary gland hyperplasia and adenocarcinomas in male and female miceCell, 1988
- The int genes in mammary tumorigenesis and in normal developmentTrends in Genetics, 1988
- Structural rearrangements of chromosome Nr 8 involving 8q12?a primary event in pleomorphic ademona of the parotid glandGenetica, 1987
- Aberrations of chromosome 8 in mixed salivary gland tumors—Cytogenetic findings on seven casesCancer Genetics and Cytogenetics, 1987
- Rearrangements of chromosome region 12q13→q15 in pleomorphic adenomas of the human salivary gland (PSA)Cytogenetic and Genome Research, 1987
- SAS für Anfänger1987
- Histogenesis of salivary gland pleomorphic adenoma (mixed tumor) with an evaluation of the role of the myoepithelial cellHuman Pathology, 1982
- The mixed salivary gland tumor — A normally benign human neoplasm frequently showing specific chromosomal abnormalitiesCancer Genetics and Cytogenetics, 1980