Metformin inhibits nerve growth factor-induced sympathetic neuron differentiation through p35/CDK5 inhibition
- 1 June 2024
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Cell Physiology
- Vol. 326 (6) , C1648-C1658
Abstract
This study unveils a novel mechanism influenced by metformin during sympathetic neuronal differentiation. By elucidating its inhibitory effects from the nerve growth factor (NGF) receptor, TrkA, to the p35/CDK5 signaling pathways, we advance our understanding of metformin’s mechanisms of action and emphasize its potential significance in the context of drug responses during sympathetic neuronal differentiation.Keywords
Funding Information
- National Science and Technology Council (109-2320-B-005-004-MY3)
- National Science and Technology Council (112-2320-B-005-008)
- National Science and Technology Council (109-2911-I-005-503)
- Taichung Veterans General Hospital (TCVGH-NCHU1117614)
- Tung's Taichung metro harbor hospital ((TTMHH-R1120062),(TTMHH-NCHULS112004))
This publication has 83 references indexed in Scilit:
- Regulation of AMPK activity by type 10 adenylyl cyclase: contribution to the mitochondrial biology, cellular redox and energy homeostasisCellular and Molecular Life Sciences, 2019
- Metformin protects PC12 cells and hippocampal neurons from H2O2‐induced oxidative damage through activation of AMPK pathwayJournal of Cellular Physiology, 2019
- Interaction of Cdk5 and cAMP/PKA Signaling in the Mediation of Neuropsychiatric and Neurodegenerative Diseases2017
- The mechanisms of action of metforminDiabetologia, 2017
- Metformin Accelerates Glycolytic Lactate Production in Cultured Primary Cerebellar Granule NeuronsNeurochemical Research, 2017
- Axon diameter relates to synaptic bouton size: structural properties define computationally different types of cortical connections in primatesBrain Structure and Function, 2016
- Human synapsin I mediates the function of nuclear respiratory factor 1 in neurite outgrowth in neuroblastoma IMR‐32 cellsJournal of Neuroscience Research, 2009
- The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1)Diabetologia, 2006
- Heterogeneous expression of SNAP‐25 and synaptic vesicle proteins by central and peripheral inputs to sympathetic neuronsJournal of Comparative Neurology, 2003
- NT-3, like NGF, Is Required for Survival of Sympathetic Neurons, but Not Their PrecursorsDevelopmental Biology, 1999