Ranked placement of phage predation as a determinant of dehydration severity among cholera patients in Bangladesh

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Abstract
Virulent bacteriophages (phages) can kill bacterial prey, potentially reducing burden of infection. In cholera, a high phage to Vibrio cholerae ratio is associated with mild dehydration, yet the relative importance of this ratio in disease severity remains unclear. We used machine learning to rank select host, microbial, and environmental factors as determinants of dehydration severity in over 600 cholera patients from across Bangladesh. We found the phage:pathogen ratio ranked among the top classifiers for mild dehydration, behind age and location. We advocate that phage predation be included as a key factor in cholera characterization for scientific, clinical and epidemiological applications.
Funding Information
  • National Institutes of Health (R21TW010182)
  • National Institutes of Health (S10 OD021758-01A1)
  • University of Florida
  • departments of Pediatrics
  • Children's Miracle Network Hospitals
  • Canadian Institutes for Health Research Project Grant

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