Dietary 5-demethylnobiletin inhibits cigarette carcinogen NNK-induced lung tumorigenesis in mice
Authors:
- 26 January 2017
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Food & Function
- Vol. 8 (3) , 954-963
Abstract
The inhibitory effects of dietary 5-demethylnobiletin, a unique citrus flavonoid, on NNK-induced lung tumorigenesis and the potential roles of its metabolites are reported.Keywords
Funding Information
- American Institute for Cancer Research (10A044)
- National Institutes of Health (CA139174)
- U.S. Department of Agriculture (Special Grant on bioactive food components)
This publication has 49 references indexed in Scilit:
- Nicotine and lung cancerJournal of Carcinogenesis, 2013
- Metabolic conversion of dietary flavonoids alters their anti-inflammatory and antioxidant propertiesFree Radical Biology and Medicine, 2011
- The inhibitory effects of 5‐hydroxy‐3,6,7,8,3′,4′‐hexamethoxyflavone on human colon cancer cellsMolecular Nutrition & Food Research, 2011
- The p53‐, Bax‐ and p21‐dependent inhibition of colon cancer cell growth by 5‐hydroxy polymethoxyflavonesMolecular Nutrition & Food Research, 2010
- p21 in cancer: intricate networks and multiple activitiesNature Reviews Cancer, 2009
- Monodemethylated polymethoxyflavones from sweet orange (Citrus sinensis) peel Inhibit growth of human lung cancer cells by apoptosisMolecular Nutrition & Food Research, 2009
- Synergistic Inhibition of Lung Tumorigenesis by a Combination of Green Tea Polyphenols and AtorvastatinClinical Cancer Research, 2008
- Extensive Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in SmokersCancer Epidemiology, Biomarkers & Prevention, 2008
- Inhibitory effects of 7-hydroxy-3-methoxy-cadalene on 4-(methylinitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis in A/J miceCancer Letters, 2004
- WAF1, a potential mediator of p53 tumor suppressionCell, 1993