Genetic Susceptibility in Dupuytren’s Disease: Lack of Association of a Novel Transforming Growth Factor β2 Polymorphism in Dupuytren’s Disease

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Abstract
The genes involved in the pathogenesis of Dupuytren’s disease have yet to be identified. In this study, we tested for an association between Dupuytren’s disease (DD) and a novel insertion polymorphism within the 5′-untranslated region (5′-UTR), of the TGFβ2 gene. DNA samples from 179 DD patients and 187 ethnically matched controls were examined. There was no statistically significant difference in TGFβ2 allele frequency distributions between cases and controls for the TGFβ2 polymorphism.

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