Immunohistologic study of cellular populations of histiocytofibromas („dermatofibromas”)

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Abstract
Histiocytofibromas (HF) are benign tumors of the skin, the cellular composition of which is not yet known with certainty. The immunohistologic characteristics of 5 lesions were studied by using monoclonal antibodies and an indirect immunofluorescence method. All tumors contained HLA-DR(+) cells, and, to a minor degree, OKM1(+) cells. OKT6(+) cells were present in the epidermis overlying the tumors; however in the HF themselves, no OKT6(+) cells were found. The presence of HLA-DR(+) and OKM1(+) cells demonstrates that HF contain cells bearing antigenic characteristics of histiocytes but not of Langerhans'' cells. The term histiocytofibroma is a more accurate designation for these lesions than dermatofibroma.

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