Easy Ruthenium‐Catalysed Oxidation of Primary Amines to Nitriles under Oxidant‐Free Conditions
- 9 July 2019
- journal article
- research article
- Published by Wiley in Chemistry – A European Journal
- Vol. 25 (58) , 13271-13274
Abstract
A dehydrogenation of primary amine to give the corresponding nitrile under oxidant‐ and base‐free conditions catalysed by simple [Ru(p‐cym)Cl2]2 with no extra ligand is reported. The system is highly selective for alkyl amines, whereas benzylamine derivatives gave the nitrile product together with the imine in a ratio ranging from 14:1 to 4:1 depending on the substrate. Preliminary mechanistic investigations have been performed to identify the key factors that govern the selectivity.Keywords
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