Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR
Authors:
- 27 January 2020
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 56 (14) , 2099-2102
Abstract
G-quadruplexes (G4s) are frequently formed in the promoter regions of oncogenes, considered as promising drug targets for anticancer therapy. Due to high structure similarity of G4s, discovering ligands selectively interacting with only one G4 is extremely difficult. Here, mainly by NMR, we report that colchicine selectively binds to oncogene RET G4-DNA.Keywords
Funding Information
- National Natural Science Foundation of China (21778065)
- National Natural Science Foundation of China (21807105)
- National Natural Science Foundation of China (21977110)
- National Natural Science Foundation of China (91753119)
- National Key Research and Development Program of China (2017YFE0108200)
- National Key Research and Development Program of China (2016YFA0502302)
- Chinese Academy of Sciences (XDB 20000000)
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