Palladium-Catalyzed Carbonylative Dearomatization of Indoles to Achieve Carbonyl-Containing Spirocyclic Indolenines Bearing an All-Carbon Quaternary Center

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Abstract
A Pd-catalyzed carbonylative dearomatization via an acyl Pd complex has been developed. Diversified carbonyl-containing spirocyclic indolenines with an all-carbon quaternary center were constructed in an efficient and straightforward way with good to excellent yields. The protocol features a simple catalytic system, operational simplicity, a broad substrate scope, easy scale-up, and versatile transformations. In addition, the asymmetric reaction was initially explored with moderate enantioselectivity.
Funding Information
  • Jiangsu Provincial Department of Education (KYCX2022-05)
  • Jiangsu Key Laboratory of Function Control Technology for Advanced Materials (jsklfctam202106)
  • Natural Science Foundation of Jiangsu Higher Education Institution of China (21KJB150006)

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