Facile fabrication of microfluidic surface-enhanced Raman scattering devices via lift-up lithography

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Abstract
We describe a facile and low-cost approach for a flexibly integrated surface-enhanced Raman scattering (SERS) substrate in microfluidic chips. Briefly, a SERS substrate was fabricated by the electrostatic assembling of gold nanoparticles, and shaped into designed patterns by subsequent lift-up soft lithography. The SERS micro-pattern could be further integrated within microfluidic channels conveniently. The resulting microfluidic SERS chip allowed ultrasensitive in situ SERS monitoring from the transparent glass window. With its advantages in simplicity, functionality and cost-effectiveness, this method could be readily expanded into optical microfluidic fabrication for biochemical applications.
Funding Information
  • Opening Measuring Fund of Precious Apparatus of Fuzhou University (2016T031)
  • Open Project of State Key Laboratory of Physical Chemistry of Solid Surfaces in Xiamen University (201201)
  • National Natural Science Foundation of China (21444007, 21504105)
  • Natural Science Foundation of Jiangsu Province (BK20130008, BK20130345)

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