Seven New Microcystins Possessing Twol-Glutamic Acid Units, Isolated fromAnabaenasp. Strain 186

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Abstract
Electrospray ionization mass spectrometry has been applied to the structure assignment of seven new microcystins (1−7), obtained from cultured Anabaena sp. strain 186. The seven new microcystins contain the dehydroalanine (Dha) or l-Ser unit instead of the N-methyldehydroalanine unit and the l-Glu and/or its δ-methyl ester [E(OMe)] units at the two variable l-amino acid units, and the structures were assigned as [Dha7]microcystin-E(OMe)E(OMe) (1), [d-Asp3,Dha7]microcystin-E(OMe)E(OMe) (2), [l-Ser7]microcystin-E(OMe)E(OMe) (3), [d-Asp3,l-Ser7]microcystin-E(OMe)E(OMe) (4), [Dha7]microcystin-EE(OMe) (5), [d-Asp3,Dha7]microcystin-EE(OMe) (6), and [l-Ser7]microcystin-EE(OMe) (7). These microcystins are the first examples containing dicarboxylic amino acids at the two variable l-amino acid units in microcystins.

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