Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones

Authors:

ANAntonio Francisco Nogueira
Antonio Francisco Nogueira
EAElisa Carvalho Azevedo
Elisa Carvalho Azevedo
Vitor Francisco Ferreira
Vitor Francisco Ferreira
Ana Jersia Araujo
Ana Jersia Araujo
Evelyne Alves dos Santos
Evelyne Alves dos Santos
CPClaudia Pessoa
Claudia Pessoa
LCLeticia Veras Costa-Lotufo
Leticia Veras Costa-Lotufo
RMRaquel Carvalho Montenegro
Raquel Carvalho Montenegro
MMManoel Odorico de Moraes
Manoel Odorico de Moraes
Thatyana Rocha Alves Vasconcelos
Thatyana Rocha Alves Vasconcelos

1 October 2010

journal article
Published by Elsevier in Letters in Drug Design & Discovery

Vol. 7 (8) , 551-555
DOI:10.2174/157018010792062740

Abstract

A series of eleven (E)-2-benzothiazole hydrazones were synthesized and evaluated for their in vitro anticancer activities against three neoplastic cancer cells: HL-60 (leukemia), MDAMB-435 (breast) and HCT-8 (colon). Two of them, 3e and 3f, showed good cytotoxicity activity for HL-60. The results also demonstrated that compound 3f seems to be selective to HL-60 cell line, appearing as a good prototype for an antileukemia lead molecule.

Synthesis and Antitumor Evaluation of (E)-2-Benzothiazole Hydrazones

Abstract

Keywords