A conserved phosphatase destroys toxic glycolytic side products in mammals and yeast
- 13 June 2016
- journal article
- research article
- Published by Springer Nature in Nature Chemical Biology
- Vol. 12 (8) , 601-607
Abstract
The glycolytic enzymes GAPDH and pyruvate kinase produce 4-phosphoerythronate and 2-phospho-L-lactate, which block metabolic flux. A newly identified conserved metabolic repair enzyme, phosphoglycolate phosphatase, eliminates these side products.Keywords
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