Engineering Fully Human Monoclonal Antibodies from Murine Variable Regions
Authors:
- Sher KarkiSKSher Karki
- Gregory L. MooreGMGregory L. Moore
- Irene W.L. LeungILIrene W.L. Leung
- Hsing ChenHCHsing Chen
- Erik PongEPErik Pong
- Duc-Hanh T. NguyenDNDuc-Hanh T. Nguyen
- Jonathan JacintoJJJonathan Jacinto
- Jonathan ZalevskyJZJonathan Zalevsky
- Umesh S. MuchhalUMUmesh S. Muchhal
- John R. DesjarlaisJDJohn R. Desjarlais
- Greg A. LazarGLGreg A. Lazar
- 1 March 2010
- journal article
- Published by Elsevier in Journal of Molecular Biology
- Vol. 396 (5) , 1474-1490
Abstract
No abstract availableKeywords
This publication has 36 references indexed in Scilit:
- Ultra-potent Antibodies Against Respiratory Syncytial Virus: Effects of Binding Kinetics and Binding Valence on Viral NeutralizationJournal of Molecular Biology, 2005
- Antibody humanization by framework shufflingMethods, 2005
- SDR grafting of a murine antibody using multiple human germline templates to minimize its immunogenicityMolecular Immunology, 2004
- Identification of differences in the specificity‐determining residues of antibodies that recognize antigens of different size: implications for the rational design of antibody repertoiresJournal of Molecular Recognition, 2004
- Fully synthetic human combinatorial antibody libraries (HuCAL) based on modular consensus frameworks and CDRs randomized with trinucleotides 1 1Edited by I. A. WilsonJournal of Molecular Biology, 2000
- A Combinatorial Library Strategy for the Rapid Humanization of Anticarcinoma BR96 FabJournal of Biological Chemistry, 1996
- Construction and initial characterization of a mouse-human chimeric anti-TNF antibodyMolecular Immunology, 1993
- Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulinsJournal of Molecular Biology, 1990
- Canonical structures for the hypervariable regions of immunoglobulinsJournal of Molecular Biology, 1987
- Replacing the complementarity-determining regions in a human antibody with those from a mouseNature, 1986