Detection of isolated cerebrovascular β‐amyloid with pittsburgh compound B
Authors:
- Steven M. GreenbergSGSteven M. Greenberg
- M. Edip GurolMGM. Edip Gurol
- Maureen E. SkehanMSMaureen E. Skehan
- Monica Garcia‐AllozaMGMonica Garcia‐Alloza
- Eric E. SmithESEric E. Smith
- 1 November 2008
- journal article
- case report
- Published by Wiley in Annals of Neurology
- Vol. 64 (5) , 587-591
Abstract
Imaging of cerebrovascular β‐amyloid (cerebral amyloid angiopathy) is complicated by the nearly universal overlap of this pathology with Alzheimer's pathology. We performed positron emission tomographic imaging with Pittsburgh Compound B on 42‐year‐old man with early manifestations of Iowa‐type hereditary cerebral amyloid angiopathy, a form of the disorder with little or no plaque deposits of fibrillar β‐amyloid. The results demonstrated increased Pittsburgh Compound B retention selectively in occipital cortex, sparing regions typically labeled in Alzheimer's disease. These results offer compelling evidence that Pittsburgh Compound B positron emission tomography can noninvasively detect isolated cerebral amyloid angiopathy before overt signs of tissue damage such as hemorrhage or white matter lesions. Ann Neurol 2008;64:587–591Keywords
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