Intermittent chemoprophylaxis for Pneumocystis carinii pneumonia

Authors:
  • WHW T Hughes
    W T Hughes
  • BSB L Smith
    B L Smith
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Abstract
An intermittent regimen of trimethoprim-sulfamethoxazole was tested in the corticosteroid-treated rat model to learn whether or not administration for 3 consecutive days a week would provide prophylaxis equal to continuous daily doses. Although all of the untreated control animals acquired Pneumocystis carinii pneumonia, none of the animals given either continuous or intermittent trimethoprim-sulfamethoxazole became infected.

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