Calculation of steady-state distribution delay between central and peripheral compartments in two-compartment models with infusion regimen
Author:
- 1 December 2002
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 27 (4) , 259-264
Abstract
A lag time may exist between blood drug concentration and drug effect. Various factors can contribute to the lag time, among which the drug distribution delay is a significant one. The drug distribution delay can also exist between different compartments. An equation was derived to calculate the steady-state drug concentration delay between central and peripheral compartments in a two-compartment model with infusion regimen.Keywords
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