New Alkaloids from Hippeastrum papilio (Ravenna) Van Scheepen

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Abstract
A new phytochemical study of the indigenous Brazilian species Hippeastrum papilio is reported herein. Three novel Amaryllidaceae alkaloids were isolated, including hippapiline (1), papiline (2), and 3‐O‐demethyl‐3‐O‐(3‐hydroxybutanoyl)haemanthamine (3). Their structures were determined by physical and spectroscopic methods. In addition, the known alkaloids, haemanthamine (4), galanthamine (5), narwedine (6), 11β‐hydroxygalanthamine (7), apogalanthamine (8), and 9‐O‐demethyllycosinine B (9) were identified. The unusual cis‐B/C‐ring fusion for the new homolycorine representative hippapiline was ratified by NMR and CD spectroscopy.