Association Between Major Depressive Episodes in Patients With Chronic Kidney Disease and Initiation of Dialysis, Hospitalization, or Death

Authors:
Open Access
Publisher website
Google Scholar
Abstract
Depression is associated with poor cardiovascular outcomes1-3 and is found to be prevalent in patients with chronic kidney disease (CKD), affecting up to 20% of patients even before initiation of dialysis.4 Approximately 13% of the US adult population has CKD, and it is well recognized as an independent predictor of cardiovascular morbidity and mortality.5-7 Moreover, those with CKD are more likely to die from cardiovascular disease than to progress to end-stage renal disease (ESRD).8 Patients who survive to progress to ESRD experience a mortality rate of 21% in their first year of dialysis6 compared with 0.5% for the general US population,9 with cardiovascular disease accounting for 50% of all deaths.6 In addition, increased hospitalizations and dialysis care for ESRD patients result in substantial health care costs, such that expenditures consumed $24 billion in 2007, approximately 6% of the entire Medicare budget.6

This publication has 44 references indexed in Scilit: