Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor
- 1 August 2010
- journal article
- Published by Elsevier in Bioorganic & Medicinal Chemistry
- Vol. 18 (15) , 5489-5497
Abstract
No abstract availableKeywords
This publication has 36 references indexed in Scilit:
- Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[11C]verapamil PETEuropean Journal of Nuclear Medicine and Molecular Imaging, 2009
- A Pilot Study to Assess the Efficacy of Tariquidar to Inhibit P-glycoprotein at the Human Blood–Brain Barrier with (R)-11C-Verapamil and PETJournal of Nuclear Medicine, 2009
- Synthesis and Small-Animal Positron Emission Tomography Evaluation of [11C]-Elacridar As a Radiotracer to Assess the Distribution of P-Glycoprotein at the Blood−Brain BarrierJournal of Medicinal Chemistry, 2009
- Evaluation of [11C]laniquidar as a tracer of P-glycoprotein: radiosynthesis and biodistribution in ratsNuclear Medicine and Biology, 2009
- P-Glycoprotein Function at the Blood–Brain Barrier Imaged Using 11C-N-Desmethyl-Loperamide in MonkeysJournal of Nuclear Medicine, 2008
- Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp FunctionJournal of Medicinal Chemistry, 2008
- Tariquidar-Induced P-Glycoprotein Inhibition at the Rat Blood–Brain Barrier Studied with (R)-11C-Verapamil and PETJournal of Nuclear Medicine, 2008
- Modulation of P-Glycoprotein at the Blood-Brain Barrier: Opportunities to Improve Central Nervous System PharmacotherapyPharmacological Reviews, 2008
- P-Glycoprotein and Breast Cancer Resistance Protein: Two Dominant Transporters Working Together in Limiting the Brain Penetration of TopotecanClinical Cancer Research, 2007
- Targeting multidrug resistance in cancerNature Reviews Drug Discovery, 2006