Chemoselective backbone cyclization of unprotected peptides

Authors:
  • JCJulio A. Camarero
    Julio A. Camarero
  • TMTom W. Muir
    Tom W. Muir
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Abstract
A fully unprotected 15 residue peptide containing an N-terminal Cys residue and a C-terminal thioester moiety is cleanly converted to the corresponding head-to-tail cyclic peptide in aqueous buffers at around neutral pH.