The Amino‐Acid Sequence of the α Subunit in Bovine Brain S‐100a Protein

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Abstract
The brain specific S‐100 protein is a mixture of two components S‐100a and S‐100b with a subunit composition αβ or β2 respectively. The amino acid sequence of the β subunit has been previously determined. This paper presents the sequence of the α subunit in the S‐100a protein. The α subunit consists of 93 amino‐acid residues and has a relative molecular mass of 10400. The sequence shows extensive homology (58%) with that of the β‐subunit and shares an apparent calcium binding site in the C‐terminal half of the molecule, suggesting a close evolutionary relationship between these subunits.

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