Ribofuranosyl Triazolone: A Natural Product Herbicide with Activity on Adenylosuccinate Synthetase Following Phosphorylation
Authors:
- 3 May 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 63 (6) , 777-781
Abstract
2,4-Dihydro-4-(β-d-ribofuranosyl)-1,2,4(3H)-triazol-3-one (2) was identified as the principal phytotoxic component of a fermentation broth derived from an Actinomadura. The compound is a new natural product, but known by synthesis. Broad-spectrum herbicidal activity was demonstrated in greenhouse tests. Metabolite reversal studies suggested the target site was adenylosuccinate synthetase, which was confirmed by direct measurement of the activity of the 5‘-phosphorylated derivative on the isolated enzyme.Keywords
This publication has 7 references indexed in Scilit:
- Natural Products in Crop ProtectionChimia, 1998
- Isolation and Structure Elucidation of Novel Neuronal Cell Protecting Substances, Carbazomadurins A and B Produced by Actinomadura madurae.The Journal of Antibiotics, 1997
- The mode of action and the structure of a herbicide in complex with its target: binding of activated hydantocidin to the feedback regulation site of adenylosuccinate synthetase.Proceedings of the National Academy of Sciences, 1996
- 2α-Phosphohydantocidin: Thein VivoAdenylosuccinate Synthetase Inhibitor Responsible for Hydantocidin PhytotoxicityPesticide Biochemistry and Physiology, 1996
- Adenylosuccinate Synthetase: Site of Action of Hydantocidin, a Microbial PhytotoxinPlant Physiology, 1996
- Syntheses and structure assignments of six azolinone ribonucleosidesThe Journal of Organic Chemistry, 1982
- Chapter XI Actinomycetes1971