Why is there no morphine concentration–response curve for acute pain?

This publication has 68 references indexed in Scilit:

• Race and Unequal Burden of Perioperative Pain and Opioid Related Adverse Effects in Children
  Pediatrics, 2012
• Pharmacogenetics of new analgesics
  British Journal of Pharmacology, 2011
• Polymorphism in the Interleukin-1 Receptor Antagonist Gene Is Associated with Serum Interleukin-1 Receptor Antagonist Concentrations and Postoperative Opioid Consumption
  Anesthesiology, 2011
• Inhibition of Morphine Metabolism by Ketamine
  Drug Metabolism and Disposition, 2010
• Evaluation of potential sex differences in the subjective and analgesic effects of morphine in normal, healthy volunteers
  Psychopharmacology, 2009
• Can UGT1A1 genotyping reduce morbidity and mortality in patients with metastatic colorectal cancer treated with irinotecan? An evidence-based review
  Genetics in Medicine, 2009
• Proinflammatory cytokines oppose opioid-induced acute and chronic analgesia
  Brain, Behavior, and Immunity, 2008
• The Relationship Between Bispectral Index and Propofol During Target-Controlled Infusion Anesthesia: A Comparative Study Between Children and Young Adults
  Anesthesia & Analgesia, 2008
• In vitro–in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: Pitfalls and promises
  Biochemical Pharmacology, 2006
• Morphine Metabolite Pharmacokinetics during Venoarterial Extra Corporeal Membrane Oxygenation in Neonates
  Clinical Pharmacokinetics, 2006