Negishi coupling: an easy progress for C–C bond construction in total synthesis
- 7 March 2014
- journal article
- review article
- Published by Springer Nature in Molecular Diversity
- Vol. 18 (2) , 441-472
Abstract
Negishi cross-coupling reactions were used extensively in total synthesis. The expansion of substrate scope, the development of mild reaction conditions, the advancement of the methods to improve the stereo- and regio-selectivity of carbon–carbon bond formation, the maturity of a large number of sequential processes, and the development of non-toxic reactions signify the importance of Negishi coupling. The following review illustrates a strategic role of this reaction in constructing carbon–carbon bonds in the recent total synthesis of natural products.Keywords
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